Antispasmodic Phloroglucinol Injection For Spasmodic Pain
Model No.: DAWAAPI0001
Phloroglucinol is an organic compound that is used in the synthesis of pharmaceuticals and explosives. It is a phenol derivative with antispasmodic properties that is used primarily as a laboratory reagent.
Phloroglucinol is also generally found in the flavonoid ring A substitution pattern.
Phloroglucinol (1,3,5-benzenetriol) is a benzenetriol, found along with two isomers, hydroxyquinol (1,2,4-benzenetriol) and pyrogallol (1,2,3-benzenetriol).
Phloroglucinol, and its benzenetriol isomers, are still defined as "phenols" according to the IUPAC official nomenclature rules of chemical compounds. Many such monophenolics are often termed "polyphenols" by the cosmetic and parapharmaceutical industries, but they cannot be by any scientifically-accepted definition.
This molecule has a unique symmetric arene substitution pattern of a trisubstituted benzene. It is a type of enol and exists in two forms, or tautomers; 1,3,5-trihydroxybenzene, which has phenol-like character, and 1,3,5-cyclohexanetrione (phloroglucin), which has ketone-like character. These two tautomers are in equilibrium.
Phloroglucinol is a useful intermediate because it is polyfunctional. Furthermore, the deprotonated intermediate in the interconversion of the two forms, referred to as an enolate anion, is important in carbonyl chemistry, in large part because it is a strong nucleophile.
From water, phloroglucinol crystallizes as the dihydrate, which has a melting point of 116-117 °C, but the anhydrous form melts at a much higher temperature, at 218-220 °C. It does not boil intact, but it does sublime.
Phloroglucinol was originally isolated from phloretin, a compound found in fruit trees, using potassium hydroxide. Additionally, the compound can be similarly prepared from glucosides, Plant Extracts and resins such as quercetin, catechin and phlobaphenes.
It is synthesized via a number of processes, but representative is the following route from trinitrobenzene. It is a selective trinitration where benzene is symmetrically trinitrated to 1,3,5 trinitrobenzene to produce a precursor for the synthesis of phloroglucinol.
The synthesis is noteworthy because ordinary aniline derivatives are unreactive toward hydroxide. Because the triaminobenzene also exists as its imine tautomer, it is susceptible to hydrolysis.
Potential health effects
It is also used as a treatment for gallstones, spasmodic pain and other related gastrointestinal disorders. It has a non-specific spasmolytic action on the vessels, bronchi, intestine, ureters and gall bladder, and is used for treating disorders of these organs. It is the main ingredient of the drug Spasfon, commercialized in France, where it is one of the most sold drugs.
Phloroglucinols acylated derivatives have a fatty acid synthase inhibitory activity.
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